株式会社ビセラ研究所
NMN ATHLETE "TWENTY-FIVE" SUPPLEMENT 100 tablets (NMN ATHLETE 25000)
NMN ATHLETE "TWENTY-FIVE" SUPPLEMENT 100 tablets (NMN ATHLETE 25000)
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NMN (Nicotinamide Mononucleotide) is recommended for those who want to efficiently take NMN and maintain their health and beauty.
Currently, clinical trials are being conducted in universities in Japan and around the world to study the oral intake of NMN.
●NMN Oral Intake Clinical Trial Summary (250mg/day, 12 weeks of administration)
Nicotinamide mononucleotide (NMN) is a vitamin B3 (niacin) derivative that acts as a precursor to nicotinamide adenine dinucleotide (NAD⁺) in cells. NAD⁺ is an important coenzyme involved in metabolism, DNA repair, and sirtuin activation, as well as aging and energy metabolism. In recent years, clinical trials mainly in Japan have been conducted to confirm the effects of increasing NAD⁺ and safety through oral intake of NMN.
Study Outline (250mg/day, 12 weeks of administration)
|
Research Institution / Country |
Subjects / Design |
Number of Subjects |
Primary Endpoints |
Summary of Results |
|
Keio University / University of Tokyo Joint Research (Japan) |
Healthy elderly men, randomized double-blind placebo-controlled |
n=25 (NMN group) / n=25 (placebo group) |
Blood NAD⁺ levels, muscle strength, walking speed |
NAD⁺ in the blood significantly increased in the NMN group. Lower limb muscle strength and walking speed also showed improvement. Safety was good. |
|
Waseda University / University of Tsukuba Joint Research (Japan) |
Middle-aged and elderly men and women, randomized double-blind placebo-controlled |
n=108 |
Sleep quality, fatigue, physical function |
The NMN group showed improved sleep quality and reduced fatigue. No safety issues. |
|
Keio University / Keio Hospital (Japan) |
Healthy adult men, single dose and 12 weeks of administration (exploratory) |
n=15 |
Blood NMN metabolites, NAD⁺-related metabolism |
250mg administration increased blood NMN metabolites. Good tolerability, no side effects. |
Overall Results
In major clinical trials (all conducted in Japan), oral administration of 250mg of NMN per day for 12 weeks showed the following results:
・Blood NAD⁺ levels significantly increased (average 20-40% increase)
・Tendency for improvement in physical functions such as muscle strength and walking speed
・Reported improvements in sleep quality and fatigue
・No serious side effects reported, safety judged as good
Discussion and Future Directions
In all trials where 250mg/day of NMN was taken for 12 weeks, an increase in blood NAD⁺ was confirmed, suggesting the potential for effectiveness against age-related metabolic and physical decline.
References
1. 1. Irie J. et al., Endocrine Journal, 2020.
2. 2. Okabe K. et al., Frontiers in Nutrition, 2022.
3. 3. Igarashi M. et al., Nature Aging, 2022.
4. 4. UMIN Clinical Trials Registry, UMIN000036321 (Japanese registered trial).
NMN ATHLETE "TWENTY-FIVE THOUSAND (25000)" supplement is for:
・Those who want to simply take NMN.
・Those who are interested in health and beauty and want to continue taking one capsule daily for about 3 months, as per university experiments.
Each capsule contains 250mg of NMN. Please take 1 to 2 capsules (250mg to 500mg of NMN) per day as a guide.
250mg of NMN can be taken per capsule.
NMN (domestically manufactured) 25,000mg
Contains no animal-derived ingredients and no allergens (28 specific raw materials).
No colorants used.
Usage Instructions
Take 1 to 2 capsules daily with water or lukewarm water.
Ingredients
β-Nicotinamide mononucleotide (NMN / domestically produced) / HPMC, cellulose, calcium stearate
・NMN (Nicotinamide Mononucleotide)
NMN is a metabolite of niacin (Vitamin B3) called β-Nicotinamide mononucleotide. It is also an ingredient found in breast milk, edamame, broccoli, and avocado, and is a type of vitamin B3. It is believed that niacin from food is converted into NMN in the body, which then produces coenzymes that activate sirtuin genes. By activating sirtuin genes, signals are sent to all functions in the body. Since coenzymes that activate sirtuin genes cannot be sufficiently supplemented through daily meals alone, a decrease in coenzyme levels leads to a decrease in signal strength, causing various functions to decline and making the body prone to illness. Therefore, artificially ingesting NMN is thought to regulate the balance of our bodies and skin.
Country of Origin: Japan
Precautions
Please refer to the raw materials and avoid use if you have food allergies. If you experience any adverse reactions, discontinue use and consult a doctor. Before opening: Store in a cool place, away from high temperatures, humidity, and direct sunlight. After opening: Close the lid tightly, store in the refrigerator, and consume as soon as possible.
